Although personal rates of cancer were similar among individuals with AJ founder variants and those with other variants (28.8% vs. 27.5%, chi-squared p = 0.97), knowledge of BRCA1/2 variant status varied: 31 of 80 (38.8%) individuals with AJ founder variants had documented evidence of clinical genetic testing, compared with only 27 of 138 (19.6%) individuals harboring other BRCA1/2 variants (chi-squared p = 3.4 × 10− 3). This evidence concerns the gene BRCA1 and cancer.