In a multivariate logistic regression analysis with age, calcification and peak enhancement in the model, we found two significant predictors for differentiating Xp11.2/TFE3 RCC from ccRCC: the presence of calcification and lower peak enhancement were more likely in Xp11.2/TFE3 RCC (P < 0.05). This evidence concerns the gene TFE3 and renal cell carcinoma.