EGFR and non-small cell lung carcinoma: To clarify the influence of acquired EGFR-TKI resistance on the efficacy of radiotherapy in the treatment of NSCLC patients with multiple BMs, and how to choose the treatment sequence between the two approaches, we assessed the clinical outcomes of WBRT in the treatment of EGFR-mutant brain metastatic NSCLC patients with or without EGFR-TKI resistance.