Serum albumin levels before and after predilution OL-HDF (from 3.85 ± 0.29 to 3.76 ± 0.33 g/dL) and MCO HD (from 3.77 ± 0.30 to 3.58 ± 0.32 g/dL) showed minimal changes with no significant difference in the RR for albumin among HF HD, predilution OL-HDF, and MCO HD (1.7 ± 3.6%, 2.3 ± 4.1%, and 4.9 ± 2.8%, respectively; P = 0.22). This evidence concerns the gene ALB and hydrops fetalis.