TNF and irritable bowel syndrome: The obtained results demonstrate that the combination of RAF of Abs to S 100, Abs to TNF-α and Abs to H has a pronounced therapeutic effect, reducing the intensity of symptoms of FGID by more than half in 80% of patients, which is consistent with previously obtained data in a multicenter, double-blind, placebo-controlled, randomized clinical trial of the efficacy and safety of using the combination of RAF of Abs to S 100, Abs to TNF-α and Abs to H for treating patients with IBS [23].