TNF and irritable bowel syndrome: According to the “7*7” questionnaire after 12 weeks of treatment with the combination of RAF of Abs to S 100, Abs to TNF-α and Abs to H, a decrease in the number of points by 50% was observed in 80.45% of patients with FD, 79.02% of patients with IBS, and in 83% of patients in the group with FD-IBS overlap (Table 3).