Administration of a selective 5-HT7 receptor agonist (AS19) in a rat model of CLP-induced sepsis results in increased survival, decreased tissue injury, a reduction in circulating inflammatory cytokines (IL-1β, IL-6 and TNF-α), an increase in antioxidant mediators (superoxide dismutase and glutathione), and a reduction in lung NF-κB (Cadirci et al. 2013). The gene discussed is TNF; the disease is Sepsis.