In this exploratory study of ART-naïve PLWHA with heavy drinking, those with advanced liver fibrosis/cirrhosis appeared to have lower prevalence of CD8+ T-cell phenotypes suggestive of immunosenescence (i.e. lower proportions CD8 + CD28-CD57+, higher naïve:memory CD8+ T-cell ratio). Here, CD28 is linked to Hepatic fibrosis.