PLIN2 and retinal degeneration: To better understand the role of Prpf31 in retinal degeneration, we have used heterozygous Prpf31A216P/+ KI mice (Bujakowska et al., 2009), a mouse model which carries the point-mutation p.A216P in the Prpf31 gene, known to be responsible for adRP in humans (Vithana et al., 2001).