PLIN2 and retinitis pigmentosa 1: Previously, two mutant mouse models (Prprf31+/− and Prpf31A216P/+) were generated to study the role of PRPF31 in the pathogenesis of adRP, but neither of these models presented evidences of RP-like photoreceptor degeneration, leading to conclude that the presence of one copy of WT-Prpf31 allele is sufficient to maintain the normal retina, and that the p.A216P mutation does not exert a dominant-negative effect (Bujakowska et al., 2009).