Using Ca2+-imaging and electrophysiological approaches in ATXN1(82Q) mice, a recent study reported a significant reduction in the responsiveness of Purkinje cells to climbing fiber activation at early-disease stage (~6 weeks) while parallel fiber–Purkinje cell transmission alteration occurred during SCA1 progression (28–40 weeks) [225]. This evidence concerns the gene ATXN1 and spinocerebellar ataxia type 1.