Chronic suppression of IP3R-mediated Ca2+ signaling by the over-expression of IP3 5-phosphatase (5PP) using adeno-associated virus in aging SCA2-58Q transgenic mice has been shown to prevent Purkinje cell death, normalize their firing pattern, and attenuate motor coordination deficits [197]. This evidence concerns the gene ITPR1 and spinocerebellar ataxia type 2.