CR1 and Alzheimer disease: For example, SNPs in genes regulating lipid homeostasis and immune function (e.g., phosphatidylinositol binding clathrin assembly protein (PICALM) for lipid metabolism and complement receptor type 1 (CR1) and triggering receptor expressed on myeloid cells 2 (TREM2) for immune regulation) have also been associated with the risk of developing AD [1,10].