Abnormal glycogen synthase kinase 3β isoform (GSK3β) activity is implicated in the pathogenesis of HF and in cardiac cell survival pathways that may interact with the LDLR, frizzled, and scavenger structural domains (i.e., non-catalytic domains) of corin (Figure 1a) [48,49,50]. The gene discussed is CORIN; the disease is hydrops fetalis.