CORIN and familial dilated cardiomyopathy: Cardiac transcripts and circulating levels of corin are depressed in patients and translational animal models with DCM and HFrEF [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,35,36,51], and are pathologically modulated in DCM before the onset of edema and other clinical signs and symptoms of HFrEF [22,23].