Costello-Boerrigter [19] in potentially healthy patients (no history of CVD (cerebrovascular disease), pulmonary disease, renal disease, DM (diabetes mellitus), no systolic and diastolic dysfunction, no cardiovascular medication, in normal sinus rhythm) in univariate analysis showed, that the highest correlation coefficients with NT-proBNP concentration were increasing age, GFR, LAVI, LV dimension index and gender. The gene discussed is NPPB; the disease is lung disorder.