Significantly increased levels of miR-195, αSMA, and periostin (Figure 4), were observed only in fibroblasts cultured in the medium from post-MI cardiomyocytes and these effects were markedly attenuated by GW4869, an inhibitor of neutral sphingomyelinase 2 (responsible for secretion of exosomes [35]). Here, SMPD3 is linked to myocardial infarction.