Through means of bioinformatic studies we identified several cardiomyocyte-specific miRNAs that enhance α-SMA expression targeting its inhibitor SMAD7 (mothers against DPP homologs 7), and we focused on miR-195 inasmuch as it has such targets predicted both in human and murine genomes and is upregulated following cardiac ischemia [33]. The gene discussed is SMAD7; the disease is myocardial ischemia.