APOE and Alzheimer disease: AD risk factors so far identified include advanced age [6,7], genetic mutations associated especially with the AβPP and ApoE genes [8,9,10,11,12,13,14], life style [15,16,17], air pollution including tobacco smoking [18,19,20,21,22], cardio-vascular diseases [23], diabetes [24], traumatic brain injury [25,26], and metal exposure [27,28,29].