MAPT and Alzheimer disease: Mercury could conceivably affect AD pathology without directly interacting with the Aβ peptides themselves [90,94], for example, via toxic molecular mimicry [157], by promoting the aggregation of the tau fragment R2 [101] and phosphorylation of the tau protein as observed in SHSY5Y neuroblastoma cells [87], or via interactions between other forms of Aβ and Hg than those studied here.