FMR1 and fragile X syndrome: For a normal child, a single seizure is not likely to substantially reduce cognitive strength, though in wildtype mice, single seizures have been demonstrated to affect long-term cognitive outcomes [91]; however, for a child whose FMRP levels are already low, early-life seizures could have a profound effect on cognitive function, underscoring the need for aggressive treatment of seizure activity in a child with fragile X syndrome or PM involvement.