Comparison of transcriptomic profiles of TSP-1 null and WT animals suggested that amino acid metabolism, PPARα and fatty acid metabolism pathways are differentially expressed in TSP-1 null mice, suggesting that these pathways may be important in TSP-1 mediated modulation of NAFLD mediated hepatic fibrosis. This evidence concerns the gene THBS1 and metabolic dysfunction-associated steatotic liver disease.