In the present PheWAS, APOE rs7412, along with nearby SNPs, were within 100kb of previously-reported GWAS associations and associated with the following lipid-related traits in a single PAGE I study (at p<1.0x10-4): total cholesterol, LDL-C, response to statin therapy, lipid metabolism phenotypes, and hypertriglyceridemia (Fig 3). The gene discussed is APOE; the disease is hypertriglyceridemia.