The synergy between TNKS and CDK4 inhibition was not restricted to DLD1 cells, as we observed similar effects of TNKS silencing and Trametinib or Palbociclib treatment in the colorectal carcinoma cell line SW480 (bearing an APC truncating mutation, similar to DLD1) (S3C Fig). This evidence concerns the gene CDK4 and colorectal carcinoma.