From our results, we found that TOB1 may function as a tumor suppressor gene in K‐Ras wild‐type pancreatic cancer and dysregulated TOB1 may partially interpret the underlying mechanism of K‐Ras wild‐type pancreatic cancer carcinogenesis, but what roles it plays in K‐Ras mutant pancreatic cancer cells deserve further study. This evidence concerns the gene KRAS and familial pancreatic carcinoma.