Hereafter, abnormal TOB1 expression has been reported in many human malignant tumors, including breast cancer,11 lung cancer,10 papillary thyroid cancer,12 skin squamous cell carcinoma, 23 and gastric cancer.24 Studies also showed that the TOB1 expression level was correlated with the clinicopathological characteristics of tumors and could be used as a prognostic marker for some tumors. This evidence concerns the gene TOB1 and skin squamous cell carcinoma.