Among transcription factors with a score greater than 0.90, Foxa2, which showed decreased expression and related to the malignant phenotype of pancreatic cancer cells, was selected for further analysis.20, 21, 22 As shown in Figure 5A, a luciferase reporter assay revealed that overexpression of Foxa2 significantly enhanced TOB1 promoter activity, indicating that Foxa2 may act upstream of TOB1 and regulate its mRNA expression. The gene discussed is TOB1; the disease is familial pancreatic carcinoma.