A previous study has revealed that the efficacy of Src inhibitors combined with EGFR inhibitors is synergistic, and Src inhibitors could improve gefitinib resistance in NSCLC with EMT.44 Our previous studies have shown that Src is involved in cigarette smoke‐induced EMT and EGFR‐TKI resistance, and Src inhibition sensitizes resistant cells to gefitinib. This evidence concerns the gene EGFR and non-small cell lung carcinoma.