Currently, multiple factors are involved in the resistance mechanisms, including the T790M secondary mutation in EGFR, HGF overexpression, MET amplification, transition into small cell lung carcinoma, obtaining cancer stem‐cell phenotypes and epithelial‐mesenchymal transition (EMT).11, 12, 13, 14 EMT is a universal phenomenon in various physiological and pathological processes. Here, EGFR is linked to cancer.