SOD2 and depressive symptom measurement: Comparison of the genotypic frequency of the Val16Ala‐SOD2 SNP in groups C and D elderly subjects is presented in Table 1, which shows that the subjects in group D had a significantly higher VV‐frequency than the healthy individuals in group C. Further analysis revealed a significant association between the VV‐genotype and depression, compared to A‐allele carriers.