Comparison of the genotypic frequency of the Val16Ala‐SOD2 SNP in groups C and D elderly subjects is presented in Table 1, which shows that the subjects in group D had a significantly higher VV‐frequency than the healthy individuals in group C. Further analysis revealed a significant association between the VV‐genotype and depression, compared to A‐allele carriers. The gene discussed is SOD2; the disease is major depressive disorder.