Guan et al. [124] demonstrated in lung cancer cells that PDPMP-mediated inhibition or knockdown of GCS potentiated ABC294640-induced antitumor activity, increased intracellular levels of ceramide, and increased apoptosis, whereas forced overexpression of GCS abrogated ABC294640 cytotoxicity against lung cancer cells. This evidence concerns the gene UGCG and lung carcinoma.