For instance, in an in vitro study, fragmented fibronectin alleviated MMP inhibition and promoted inflammatory cell migration.66 Ultimately, MMPs are thought to play an important role in disc degeneration and resorption.67 Specifically, proinflammatory cytokines such as IL‐1 and TNF‐α induce disc degeneration by contributing to decreased matrix production and increased production of degradation enzymes such as MMPs.63, 68, 69, 70. This evidence concerns the gene FN1 and intervertebral disk degenerative disorder.