Notably, we found that Wnt5a levels were gradually higher in the DKD II/III group compared with those in DKD I group (51.34 ± 4.30 ng/ml and 63.89 ± 2.57 ng/ml versus 38.02 ± 4.02 ng/ml, P < 0.001) (Fig. 1b). This evidence concerns the gene WNT5A and diabetic kidney disease.