A targeted proteomics SRM study revealed a number of predictive biomarkers related to the risk of development OSCC, namely complement proteins, CFB, C3, C4B, Alpha-1-antitrypsin protein SERPINA1, and LRG1, a protein identified before in the serum and tumours of cancer patients, all found with differentiated expression in OSCC [49]. This evidence concerns the gene SERPINA1 and cancer.