Several studies have shown that the infiltration of CD163+ MΦs positively correlates with epithelial dysplasia and the malignancy of oral precancerous lesion (Mori, Haraguchi, Hiori, Shimada, & Ohmori, 2015; Stasikowska‐Kanicka et al., 2018b). Here, CD163 is linked to intraepithelial neoplasia.