ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: In particular, K562 cells showed an upregulation of the glutamine importer SLC1A5 and the glutamine-to-glutamate converting enzyme GLUL (Fig. 4a), in line with previous data showing that overexpression of BCR-ABL in human CD34+ cells as well as primary CML patient samples display enhanced glutaminolysis [41].