Some researches have shown [17] that the inhibition of the expression of the LKB1–AMPK–GLUT4 signaling cascade in the skeletal muscle of patients with type 2 diabetes reduced the transfer efficiency of glycogen in the skeletal muscle, thus decreasing the insulin sensitivity and glucose disposal rate in the blood and increasing the blood glucose level. This evidence concerns the gene PRKAA2 and type 2 diabetes mellitus.