In a normal body, the phosphorylation of upstream tumor-inhibiting factor-1 (LKB1) that is activated can phosphorylate the Thr172 locus on AMPKa subunit and thus activate AMPK that will promote the transport process of glucose transporter-4 (GLUT4) to glucose and the processes of glucose uptake, transport, and utilization in skeletal muscle and improve the insulin resistance level of patients. Here, PRKAA2 is linked to Insulin resistance.