The algorithm has been applied to a cohort of 191 children with ID, ASD and congenital abnormalities, yielding 13 pathway clusters potentially associated with brain disorders: neurodegenerative diseases, proteasome, signaling by ERBB4, transcription regulation, regulation of TP53, signaling by NOTCH, senescence, mitosis, DNA repair, vesicles functioning, actin functioning, macromolecular interactions, B cells functioning. The gene discussed is ERBB4; the disease is brain disorder.