In line with our results of slightly reduced COX-2 protein expression in nasal polyps of AIA patients, Pujols et al. [33] showed in a real-time PCR approach analyzing the dynamics of COX-2 expression in nasal tissue of AIA and ATA patients, that the baseline concentrations of COX-2 mRNA in nasal polyps were significantly reduced as compared to the nasal mucosa in both groups. This evidence concerns the gene PTGS2 and Nasal polyposis.