Many of those proteins that were significantly changed in this investigation, have formerly been associated with colon cancer, including HLA class II histocompatibility antigen gamma chain (CD74) [36], carcinoembryonic antigen-related cell adhesion molecule-7 (CEACAM-7) [37], glutathione S-transferase omega-1 (GSTO1) [38], matrix metalloproteinase-9 (MMP-9) [35], hepatoma-derived growth factor (HDGF) [39], lactotransferrin (LTF) [40], cytoskeleton-associated protein 5 (also known as colonic and hepatic tumor overexpressed gene protein) [41] and DNA (cytosine-5)-methyltransferase 1 [42]. Here, LTF is linked to malignant colon neoplasm.