So we selected caveolin-1 (CAV-1) from the cluster C10 (Fig. 1) UDD (unchanged between benign and non-cancer tissues but decreased in both non-metastatic and metastatic and tumor as compared to non-cancer tissues) and Matrix metalloproteinase-9 (MMP-9) from the cluster C18 (Fig. 1) UII (unchanged between benign and non-cancer tissues but increased in both non-metastatic and metastatic and tumor as compared to non-cancer tissues) for further investigation. The gene discussed is CAV1; the disease is cancer.