Analysis of the frequently observed proteins by quantile box plots and ANOVA confirmed increases in mean precursor intensity in cancer associated proteins as SLC35B1, IQCJ-SCHIP1, MREG, BHMT2, LGALS7, THOC1, ANXA4, DHDDS, SAT2, PTMA, FYCO1 and ZNF562 among others between breast cancer versus ovarian cancer and/or other disease or normal plasma (Fig. 5). Here, MREG is linked to breast cancer.