PLCG1 and T-cell leukemia: In fact, PLC-γ1 is the most frequently (~40%) mutated gene in adult T cell leukemia/lymphoma, where mutant forms of the isozyme are presumed to drive oncogenesis through enhanced phospholipase activity coupled to elevated NFAT- and NF-κB-dependent transcription (Kataoka et al., 2015; Vaqué et al., 2014).