Tzeng et al reported that Radix Paeoniae Rubra promoted osteoclastogenesis partly via activation of the NF‐κB pathway.41 In a mouse model, iron‐induced oxidative stress was reported to stimulate osteoclastogenesis by upregulating the NF‐κB signalling pathway.42 Another similar study reported that FSTL1 enhanced osteoclast formation via the activation of NF‐κB.43 In addition, the inhibition of the NF‐κB pathway has been widely reported as an effective approach to inhibit osteoclast formation and prevent the development of osteoporosis. Here, FSTL1 is linked to osteoporosis.