Previous studies on postmenopausal osteoporosis showed that osteoporosis is mainly characterized by excessive osteoclastogenesis, abnormally increased osteoclastic bone resorption and deficient bone formation.6 Osteoclasts are usually differentiated from the monocyte/macrophage lineage upon stimulation with macrophage colony‐stimulating factor and receptor activator of nuclear factor‐κB ligand (RANKL). Here, TNFSF11 is linked to osteoporosis.