EREG and cancer: For example, gonadotropin induces trophoblast cell migration and invasion by EMT upregulation.32 MMP14 activation is critical for EMT and migration by regulating the levels of cadherins in the cells.33 Autocrine TGFβ/TGFβR signalling can stimulate the EMT in the cancer cells.34 Our results also provided the evidence that poFUT1, epiregulin and uPA were expressed at lower levels in trophoblast from abortion patients (Figure 1A) than normal pregnant women, and decreased level of these molecules could hamper embryo implantation by interfering the trophoblast EMT process.