With immunostaining of Tuj-1+/PSD-95+ and Tuj-1+/SYN+ expression, we found that COs transplantation increased the expression of PSD-95 and SYN at 7 dpi in the transplantation periphery of ipsilateral cortex and ipsilateral SGZ of COs transplantation group, compared with MCAO group (Fig. 6a, b), providing evidence for enhanced synaptic reconstruction by COs transplantation after stroke. The gene discussed is DLG4; the disease is Stroke.