RAD50 and colorectal cancer: MRN expression has been linked to reduced progression-free survival in patients with colorectal cancers (51), and the knockdown of Rad50 sensitizes colorectal cancer cell lines to ionizing irradiation (52); additionally, a Rad50 mutant lacking the NBDs sensitizes nasopharyngeal carcinoma to irradiation (53) highlighting the potential for allosteric inhibitors of Rad50.