IDH2 and neoplasm: If the cohort of the analysis, regardless of the technique used for image analysis (i.e., radiomics-based or CNN-based analysis), was performed without carefully discriminating the two, IDH mutation can be easily classified by age or contrast enhancement of the tumor alone, which adds no value in clinical practice, as tumor contrast enhancement has long been considered a hallmark of glioblastoma (i.e., IDH wild-type tumor) in many cases.