LDLR and atherosclerosis: Moreover, to compare the HDL-miR panel in FH patients with or without cardiovascular events, we performed another analysis and stratified the study population into three new groups according to both the LDLR genotype and history of ASCVD: LDLR-null/not-ASCVD group (20 FH patients), LDLR-defective/not-ASCVD group (26 FH patients) and LDLR/ASCVD group (21 FH patients) (Fig. 3).