We showed that HDL-miR-486 and HDL-miR-92a were more expressed in the LDLR-null group than the LDLR-defective group; moreover, we found that both the LDLR-ASCVD group and the LDLR-null group had significant HDL-miR-486 and HDL-miR-92a levels compared with the LDLR-defective group. Here, LDLR is linked to atherosclerosis.