Both the LDLR/ASCVD group and the LDLR-null/not-ASCVD group had a higher expression of HDL-miR-486 and HDL-miR-92a than the LDLR-defective/not-ASCVD group (for LDLR/ASCVD vs LDLR-defective/not-ASCVD group HDL-miR-486 and HDL-miR-92a fold change +2.0 and +2.1 respectively, p < 0.05 for both; for LDLR-null/not-ASCVD vs LDLR-defective/not-ASCVD group HDL-miR-486 and HDL-miR-92a fold change +1.7 and +1.8 respectively, p < 0.05 for both, Fig. 3A,B). Here, LDLR is linked to atherosclerosis.