The comprehensive series of GWASs presented here validates associations of obesity and BMI found in previous studies, such as the FTO and NEGR1 loci (Willer et al. 2009; Speliotes et al. 2010; Okada et al. 2012; Locke et al. 2015). Here, NEGR1 is linked to obesity due to melanocortin 4 receptor deficiency.