Although microglia were reported to be important for the production of CCL2 during acute inflammation [38], the level of Ccl2 expression was not increased in FcγRIIB−/−Yaa mice in the present study, suggesting the polarizing status of microglia during lupus is different from that in acute inflammation. The gene discussed is FCGR2B; the disease is systemic lupus erythematosus.