In the present study, we investigated immunological changes in the CNS of three strains of lupus-prone mice: FcγRIIB−/−Yaa mice, a lupus model created by the lack of FcγRIIB suppression and duplication of Toll-like receptor 7 (TLR7) by the Yaa gene [21]; an F1 hybrid between NZB and NZW (NZB/NZW) mice; and MRL/Faslpr (MRL/lpr) mice. Here, TLR7 is linked to systemic lupus erythematosus.