When recombinant lentivirus of let-7b (lenti-let-7b) was transfected into S. japonicum-infected mice, the expressions of TGF-β1, TβRI, α-SMA, collagen I, serum IL-4 and IFN-γ were significantly decreased, and liver fibrosis was significantly ameliorated [80]. Here, ACTA1 is linked to Hepatic fibrosis.