Some of the affected proteins are relevant with NADH dehydrogenase, Ndufb5, Ndufb6, Ndufa7 and ubiquinol-cytochrome c reductase complex Uqcc2 of mitochondria (Fig. 5b and c) have network relation (Fig. 5d) based on the results of the David Bioinformatics Resources database (https://david.ncifcrf.gov/) (Table 3), suggesting the multi-targets and synergic effect of BBR on the CORT induced depressive disorder. Here, ENSG00000254051 is linked to depressive disorder.