In HAM/TSP disease, PSMB8 in associated with PSMB8, JAK2, STAT1, IFI35, IRF1, GBP2, IFITM1, HLA-B, ISG20, GBP5, SOCS1, BST2, IFNG, and UBE2L6 activate the Interferon Signaling pathway and Cytokine Signaling in Immune system. This evidence concerns the gene ISG20 and tropical spastic paraparesis.