(rs365990, rs7158731) is on chromosome 14, where rs365990 is in gene MYH6, and rs7158731 is in gene ZNF839. MYH6 encodes the alpha heavy chain subunit of cardiac myosin, and mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. The gene discussed is MYH6; the disease is atrial septal defect.