KDR and adenomyosis: In our in vitro experiment, we showed that VEGFR1 might be the guardian of regulation of VEGFA actions in the environment of increased E2 stimulation in a healthy tissue, since VEGFR1 expression was increased in endothelial cells incubated with control explants (non-adenomyotic) treated with both hormones, E2 and P4, while during adenomyosis this silencing mechanism was not observed, and VEGFR2 protein abundance was higher under E2 influence instead.