Several reports have demonstrated musashi1 is abnormally expressed in a variety of malignant tumors, including retinoblastoma, lung cancer, esophageal adenocarcinoma, glioma and gastrointestinal cancer [7–11], and in these malignant tumors, musashi1 is associated with tumor stem cells and affects the recurrence and metastasis of tumors. The gene discussed is MSI1; the disease is retinoblastoma.