SPINK4 and colorectal carcinoma: Furthermore, SPINK4 was confirmed as an independent indicator of poor survival in patients with CRC in multivariate Cox proportional hazard regression in all 3 databases (GSE24551, HR = 0.462, P = 0.056; GSE39582, HR = 0.636, P = 0.014; TCGA database, HR = 0.301, P = 0.014) and in our own cohort (HR = 0.299, P = 0.027 for OS; HR = 0.264, P = 0.014 for DFS) (Tables 3-4).