The third is their resemblance with the most aggressive subtypes of breast cancer, for which targeted therapies are still needed: feline mammary carcinomas (FMCs) often lack significant levels of Estrogen Receptor (ER) and Progesterone Receptor (PR) expression, are rarely positive to HER2 (Human Epidermal growth factor Receptor 2), and thus most of them are considered to be triple-negative mammary carcinomas [10–19]. The gene discussed is ESR1; the disease is breast carcinoma.