In the 180 FMCs studied, FOXA1 index ≥1% was associated with longer disease-free interval (HR = 0.60, 95% CI: 0.41–0.87, p = 0.008; Fig. 2a), longer overall survival (HR = 0.73, 95% CI: 0.53–0.99, p = 0.049), and longer cancer-specific survival (HR = 0.60, 95% CI: 0.42–0.85; p = 0.007; Fig. 2b) by univariate survival analysis. The gene discussed is FOXA1; the disease is cancer.