Interestingly, according to the expression profiling based on the parabiosis model of ovarian cancer hematogenous metastasis, four genes (POSTN, LUM, COL3A1, COL5A2) of the LMGS were shown to be significantly up-regulated in the omental metastases generated through a hematogenous route (Additional file 2: Figure S1b). The gene discussed is COL5A2; the disease is ovarian cancer.